Lyndon West, Ph.D.
Associate Professor
Charles E. Schmidt College of Science
Chemistry and Biochemistry
Boca Raton Campus
Research Interests
Discovery of pharmacologically-active metabolites from marine invertebrates, anti-cancer and anti-microbial agents, use of stem cells in developing new drugs for cardiovascular and neurodegenerative diseases and development of novel approaches for the separation and characterization of marine natural products to accelerate the discovery of drug leads
Recent Publications
Roche, S.; Scesa, P.; Wangpaichitr, M.; Savaraj, N.;聽West, L. M.聽Kinetic Dearomatization Strategy for an Expedient Biomimetic Route to the Bielschowskysin Skeleton.聽Angew. Chem. Int. Ed.2018,聽57, 1316.
He, Y. Q.; Caplan, S. L.; Scesa, P.;聽West, L. M.聽Cyclized 9,11-secosterol enol-ethers from the gorgonian Pseudopterogorgia americana.聽Steroids聽聽聽聽2017,聽125, 47-53.
Hall, J, A.; Roche, S.;聽West, L. M.聽Synthesis of Briarane Diterpenoids: Biomimetic Transannular Oxa-6蟺 electrocyclization Induced by a UVA/UVC Photoswitch聽Org.聽Lett.聽2017, 19, 576-579.
Caplan, S. L.; Zheng, B.; Dawson-Scully, K.; White, C.;聽West, L. M.聽Pseudopterosin A: Protection of Synaptic Function and Potential as a Neuromodulatory Agent.聽Marine Drugs聽2016,聽14, 55.
He, Y.; Ma, G.; Peng, J.; Hamann, M. T.;聽West, L. M. A Iridoid Glucoside and the Related Aglycones from Cornus controversa鈥澛燡. Nat. Prod.聽2014,聽77, 2138-2143.\聽
Duckworth, A. R.;聽West, L. M.; Vansach, T.; Stubler, A.; Hardt, M. Effects of water temperature and pH on growth and metabolite biosynthesis of coral reef sponges聽Ecol. Prog. Ser.聽2012, 462, 67-77.
West, L. M.; Faulkner D. J. Acanthosulfate, a Sulfated Hydroxyhydroquinone Seserterpene form the Sponge Acanthodendrilla. J. Nat. Prod. 2008, 71, 269 -271.
West, L. M.; Faulkner D. J. Hexaprenoid hydroquinones from the Sponge Haliclona (aka Adocia) sp. J. Nat. Prod. 2006, 69, 1001-1004.
Page M. J.; West, L. M.; Northcote P. T.; Kelly-Shanks M. Spatial and Temporal Variability of Cytotoxic Metabolites in Populations of the New Zealand Sponge Mycale hentscheli (Poecilosclerida: Mycalidae) J. Chem Ecology, Chem. Ecology, 2005, 31, 1161-1174.
Fenical W.; Jensen P. R.; Kauffman C.; Mayhead S. L.; Faulkner D. J.; Sincich, C.; Rama Rao M.; Kantorowski E. J.; West L. M.; Strangman W. K.; Shimizu Y.; Li B.; Thammana S.; Drainville K.; Davies-Coleman M. T.; Kramer R. A.; Fairchild C. R.; Rose W. C.; Wild R. C.; Vite C. D.; Peterson R. W. New Anticancer Drugs from Cultured and Collected Marine Organisms. Pharm. Biology 2003, 41, 6-14.
Meragelman K. M.; West, L. M.; Northcote P. T.; Pannell, L. K.; McKee T. C.; Boyd, M. R. Unusual Sulfamate Indoles and a Novel Indolo[3,2- a] carbazole from Ancorina sp. J. Org. Chem. 2002, 67, 6671-6677.
Hood K. A.; West L. M.; Rouw, B.; Northcote P. T.; Berridge M. V.; Miller J. H. Peloruside A, a New Class of Anti-Mitotic Agent with Paclitaxel-Like Microtubule-Stabilizing Activity. Cancer Res. 2002, 62, 3356-3360.
Hood K. A.; Bckstrm, B. T, West L. M.; Northcote, P. T.; Berridge, M. V.; Miller, J. H. The Novel Cytotoxic Sponge Metabolite Peloruside A, Structurally Similar to Bryostatin-1, has Unique Bioactivity Independent of Protein Kinase C. Anti-Cancer Drug Design, 2001, 16, 155-166.
Hood K. A.; West L. M.; Northcote P. T. Berridge M. V.; Miller J. H. Induction of Apoptosis by the Marine Sponge (Mycale) Metabolites, Mycalamide A and Pateamine. Apoptosis 2001, 6, 207-219.
West L.M.; Northcote P. T.; Hood K. A.; Miller J. H.; Page, M. J. Mycalamide D, a new Cytotoxic Amide from the New Zealand Marine Sponge Mycale Species. J. Nat. Prod., 2000, 63, 707-709.
West L. M.; Northcote, P. T.; Battershill C. N. Peloruside A: A Potent Cytotoxic Macrolide Isolated from the New Zealand Marine Sponge Mycale sp. J. Org. Chem. 2000, 65, 445-449.
West L. M.; Northcote, P. T.; Battershill C. N. Two New Clerodane diterpenes from the New Zealand Marine Sponge Raspailia sp. Aust. J. Chem. 1998, 51, 1097-1101.