ÌÇÐÄVlog

Education

• Ph.D.,ÌýUniversity of Missouri, 2001

Research Interests

• Molecular mechanisms of aging and neurodegeneration
• Neuronal regulation ofÌý C. elegans Ìýlarval development
• Drug screening
• The role of autophagy in innate immunity

Research Description

In the last two decades, the study of the molecular regulation of aging in model organisms, particularly in C. elegans, has greatly expanded our knowledge of aging. Multiple longevity pathways, such as insulin-like growth factor signaling, TOR signaling, dietary restriction, and mitochondrial activity, control aging in C. elegans and other organisms. Recent genetic studies indicate that autophagy, an evolutionary conserved lysosomal degradation pathway, interacts with various longevity signals in the regulation of C. elegans life span. My lab uses C. elegans as a model organism to investigate the molecular mechanisms by which autophagy regulates aging.

Aging is a risk factor for many human diseases including cancer and neurodegeneration. As a corollary, a wide variety of mutations that extend C. elegans life span confer resistance to tumorigenesis. Autophagy is involved in preventing aging, tumorigenesis and neurodegeneration in higher eukaryotes. Thus, a better understanding of the role of autophagy in controlling C. elegans life span may contribute to the understanding of these processes in mammals.

Recent Publications

• Minnerly, J., Zhang, J., Parker, T., Kaul^,Ìý T. andÌý Jia, K.Ìý (2017). The cell non-autonomous function of ATG-18 is essential for neuroendocrine regulation ofÌý Caenorhabditis elegans Ìýlifespan. PLoS Genetics. 13(5):e1006764. doi: 10.1371/journal.pgen.1006764.
• Chen, D., Zhang, J., Minnerly, J., Kaul, T., Riddle, D. andÌý Jia, K. Ìý(2014). daf-31 encodes the catalytic subunit of N alpha-acetyltransferase that regulatesÌý Caenorhabditis elegans Ìýdevelopment, metabolism and adult lifespan. PLoS GeneticsÌý 10(10):e1004699. doi:10.1371/journal.pgen.1004699.
• Sasaki, T., Lian, S., Qi, J., Bayliss, P., Carr, C., Johnson, J., Guha, S., Kobler, P., Catz, S., Gill, M.,Ìý Jia, K., Klionsky, D.J., and Kishi, S. (2014) Aberrant autolysosomal regulation is linked to the induction of embryonic senescence: differential roles of Beclin 1 and p53 in vertebrate Spns1 deficiency. PLoS GeneticsÌý 10(6):e1004409. doi:10.1371/journal.pgen.1004409.
• Curt, A., Zhang, J., Minnerly, J., andÌý Jia, K. Ìý(2014). Intestinal autophagy activity is essential for host defense againstÌý Salmonella typhimurium Ìýinfection inÌý Caenorhabditis elegans. Developmental and Comparative ImmunologyÌý 45:214-218.