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Research Interests

The main emphasis of our research is to better understand protein-carbohydrate interactions involved in many important physiological and pathological processes. We use chemical approaches to synthesize model glycopeptides and glycopeptide libraries as tools for probing glycan biology. This research may have implications in the development of novel more effective disease-modifying therapeutic strategies for cancer and neurodegenerative diseases such as Alzheimer’s disease.

Awards and Recognition

• 2024    The Researcher of the Year, College of Science, ����Vlog
• 2023    The Distinguished Mentor of the Year Award, ����Vlog
• 2019    The Distinguished Mentor of the Year Award, College of Science, ����Vlog

Recent Publications

1. Y. Singh, D. Regmi, D. Ormaza, R. Ayyalasomayajula, N. Vela, G. Mundim, D. Du, D. Minond, and M. Cudic (2022) “Mucin-type O-Glycosylation Proximal to β-Secretase Cleavage Site Affects APP Processing and Aggregation Fate.” Front. Chem., 10:859822  
   
   
2. D. M. Beckwith, F. G. FitzGerald, M. C. Rodriguez Benavente, E. R. Mercer, A. K. Ludwig, M. Michalak, H. Kaltner, J. Kopitz, H.-J. Gabius, M. Cudic (2021) “Calorimetric Analysis of the Interplay between Synthetic Tn Antigen-Presenting MUC1 Glycopeptides and Human Macrophage Galactose-Type Lectin.”, Biochemistry, 60:547-558  
   
   
3. Y. Singh, D. Ormaza, A. Massetti, D. Minond, and M. Cudic (2021) “Tyrosine O-GalNAc Alters the Conformation and Proteolytic Susceptibility of APP Model Glycopeptides.” ACS Chem. Neurosci., 12:2974-2980.  
   
   
4. Y. Singh, M. C. Rodriguez Benavente, M. H. Al-Huniti, D. Beckwith, R. Ayyalasomayajula, E. Patino, W. S. Miranda, A. Wade, and M. Cudic (2020) “Positional Scanning MUC1 Glycopeptide Library Reveals the Importance of PDTR Epitope Glycosylation for Lectin Binding.” J. Org. Chem. 85:1434-1445.  
   
   
5. F. G. FitzGerald, M. C. Rodriguez Benavente, C. Garcia, Y. Rivero, Y. Singh, H. Wang, G. B. Fields, M. Cudic (2020) “TF-containing MUC1 glycopeptides fail to entice Galectin-1 recognition of tumor-associated Thomsen-Freidenreich (TF) antigen (CD176) in solution.” Glycoconj. J. 37:657-666.  
   
   
6. J. J. Lohmueller, S. Sato, L. Popova, I. M. Chu, M. Tucker, R. Barberena, G. Innocenti,  M. Cudic, J. D. Ham, W. Cheung, R. D. Polakiewicz, and O. J. Finn(2016) Human anti-MUC1 monoclonal antibodies produced by healthy individuals in response to a prophylactic cancer vaccine: tumor specificity and immunotherapeutic potential,  Nature Sci. Rep.  6   :  31740. PMID: 27545199 
   
   
7. A. Jakas, M. Perc, J. Suć, M. C. Rodriguez,  M. Cudic, and P. Cudic (2016) Synthesis of Anthrose lipidic derivative as mimic of  B. anthracis  BclA glycoprotein for use in ELISA-like binding assays,  J. Carbohydr. Chem.   35:69-85. 
   
   
8. M. C. Rodriguez, S. Yegorova, J-P. Pitteloud, A. E. Chavaroche, S. André, A. Ardá, D. Minond, J. Jiménez-Barbero, H-J. Gabius,and  M. Cudic  (2015) “Thermodynamic switch in binding of adhesion/growth-regulatory human galectin-3 to tumor-associated TF antigen and MUC1 glycopeptides.”  Biochemistry,  54:4462-74. PMCID:4520625 
   
   
9. S. Yegorova, A. A. E. Chavaroche, M. C. Rodriguez, D. Minond,  M. Cudic  (2012) “Analysis of low affinity glycan-lectin interactions using AlphaScreen technology.”  Anal Biochem.   439: 123-131. PMID: 15705169 
   
   
10. A. Yongye, L. Calle, A. Arda, J. Jimenez-Barbero, S. André, H.-J. Gabius, K. Martinez-Mayorga, and  M. Cudic  (2012) “Molecular Recognition of TF antigen-Threonine Conjugate by Adhesion/Growth Regulatory Galectin-3: NMR Studies and Molecular Dynamics Simulations.”  Biochemistry   51: 7278-7289. PMID: 22916968  

Other Information

• Member Editorial Board, Frontiers in Chemistry, Chemical Biology
• Member, National Certification Exam Committee, American Society for Biochemistry and Molecular Biology (ASBMB)
• Member, American Chemical Society
• Member, Society for Glycobiology
• Member, American Peptide Society